Saturday, April 3, 2021
| Final | |
| Wayland Baptist (2-4, 1-3) | 17 |
| Langston (2-2, 2-2) | 38 |
| TV/Radio: N/A | |
| Final | |
| 9 Tennessee State (2-4, 2-4) | 10 |
| Tennessee Tech (2-4, 2-4) | 24 |
| TV/Radio: N/A | |
| Postponed | |
| 1 Alabama A&M (2-0, 1-0) | -- |
| 3 Prairie View A&M (2-0, 2-0) | -- |
| TV/Radio: N/A | |
| Final | |
| 7 South Carolina State (2-1) | 14 |
| 6 Alabama State (2-2) | 7 |
| TV/Radio: N/A | |
| Final | |
| 2 Arkansas-Pine Bluff (3-0, 3-0) | 24 |
| Mississippi Valley State (0-2, 0-2) | 17 |
| TV/Radio: N/A | |
| Final | |
| 5 Southern (4-1, 4-1) | 34 |
| 4 Jackson State (3-2, 2-2) | 14 |
| TV/Radio: ESPN | |
| Canceled | |
| 10 Grambling State (0-3, 0-3) | -- |
| Texas Southern (0-2, 0-2) | -- |
| TV/Radio: N/A | |
| Final | |
| 8 Delaware State (2-1) | 37 |
| Howard (0-2) | 28 |
| TV/Radio: N/A | |