Thursday, September 9, 2021
| Final | |
| Edward Waters (1-1) | 3 |
| Benedict (2-0) | 44 |
Saturday, September 11, 2021
su_row]
| Final | |
| West Alabama (2-0) | 33 |
| Tuskegee (0-2) | 7 |
| Final | |
| Saginaw Valley State (1-1) | 19 |
| Bowie State (1-1) | 28 |
| Final | |
| Kentucky Wesleyan (1-1) | 26 |
| Kentucky State (1-1) | 25 |
| Final | |
| Central State (1-1) | 19 |
| Lincoln (PA) (0-2) | 7 |
| Final | |
| Virginia State (0-2) | 7 |
| Ohio Dominican (1-1) | 10 |
| Final 2 OT | |
| Chowan (2-0) | 46 |
| Tusculum (1-1) | 38 |
| Final | |
| Cumberlands (2-0, 1-0) | 56 |
| Florida Memorial (0-3, 0-1) | 12 |
| Final | |
| Alabama State (1-1) | 0 |
| Auburn (2-0) | 62 |
| Final | |
| Norkfolk State (0-2) | 16 |
| Wake Forest (2-0) | 41 |
| Final OT | |
| Georgetown (1-0) | 20 |
| Delaware State (1-1) | 14 |
| Final | |
| Lane (1-1, 1-0) | 35 |
| Clark Atlanta (1-1, 0-1) | 26 |
| Final | |
| 6 SC State (0-2) | 3 |
| Clemson (1-1) | 49 |
| Final | |
| Valdosta State (2-0) | 51 |
| Virginia Union (0-2) | 7 |
| Final | |
| Northwestern State (0-2) | 10 |
| Alcorn State (1-1) | 13 |
| Final | |
| Texas Southern (0-2) | 7 |
| Baylor (2-0) | 66 |
| Final | |
| Texas college (0-2, 0-1) | 6 |
| Langston (2-0, 1-0 ) | 44 |
| Final | |
| Miles (0-2) | 24 |
| 10 Southern (1-1) | 41 |
| Final | |
| 9 Grambling State (1-1) | 0 |
| Southern Miss (1-1) | 37 |
| Final | |
| 3 Jackson State (2-0) | 38 |
| Tennessee State (0-2) | 16 |
| Southern Heritage Classic, Memphis, TN | |
| Final | |
| Morgan State (0-2) | 20 |
| Tulane (1-1) | 69 |
| Final | |
| Shaw (0-2) | 26 |
| Davidson (1-1) | 28 |
| Final | |
| Fort Valley State (1-1) | 7 |
| 7 Florida A&M (1-1) | 34 |
| Final | |
| Allen (1-1) | 20 |
| Johnson C. Smith (0-1) | 19 |
| Final | |
| Livingstone (0-2) | 6 |
| Savannah State (1-1) | 50 |
| Final | |
| Morehouse (0-2) | 0 |
| West Georgia (2-0) | 47 |
| Final | |
| Fayetteville State (1-1) | 21 |
| Wingate (2-0) | 40 |
| Final | |
| Bethune Cookman (0-2) | 14 |
| UCF (2-0) | 63 |
| Final | |
| 8 NC Central (1-1) | 10 |
| Marshall (2-0) | 44 |
| Final | |
| 5Prairie View A&M (1-1) | 9 |
| Incarnate Word (1-1) | 40 |
| Final | |
| Shorter (1-1) | 12 |
| Albany State (2-0) | 28 |
| Final | |
| Winston-Salem State (0-1) | 6 |
| Catawba (1-0) | 28 |
| Canceled | |
| Saint Augustine's (0-1) | -- |
| Limestone (0-1) | -- |
| Final | |
| Howard (0-2) | 0 |
| Maryland (2-0) | 62 |
| Final | |
| Hampton (1-1) | 7 |
| Old Dominion (1-1) | 47 |
| Final | |
| Elizabeth City State (0-2) | 27 |
| Bluefield State (1-1) | 35 |
Week 1 Scores