Saturday, October 30, 2021
| Final | |
| Columbus State (5-2) | 25 |
| Allen (4-4) | 32 |
| Final | |
| Langston (7-1, 6-1) | 24 |
| Louisiana College (3-6, 3-4) | 31 |
| Final | |
| Texas College (0-9, 0-7) | 18 |
| Texas Wesleyan (6-2, 6-2) | 69 |
| Final | |
| Kentucky State (5-4, 3-2) | 42 |
| Tuskegee (3-6, 2-3) | 35 |
| Final | |
| Lane (6-3, 3-2) | 16 |
| Central State (1-8, 0-5) | 14 |
| Final | |
| Virginia Union (5-4, 4-2) | 44 |
| Elizabeth City State (3-6, 3-3) | 14 |
| Final | |
| Saint Augustine's (0-7, 0-6) | 13 |
| Johnson C. Smith (1-7, 1-5) | 34 |
| Final | |
| 5Bowie State (8-1, 6-0) | 31 |
| Lincoln (PA) (1-8, 1-5) | 7 |
| Final | |
| Monmouth (5-3, 4-0) | 35 |
| 10NC A&T (3-5, 2-3) | 16 |
| Final | |
| Winston-Salem State (3-5, 3-3) | 14 |
| Shaw (6-3, 5-1) | 38 |
| Final | |
| Glenville State (2-6, 2-6) | 28 |
| West Virginia State (5-4, 5-3) | 38 |
| Final | |
| Hampton (3-5, 1-3) | 35 |
| Robert Morris (3-4, 2-2) | 38 |
| Final | |
| Central Missouri (3-6, 3-6) | 77 |
| Lincoln (MO) (0-8, 0-8) | 35 |
| Final | |
| Arkansas-Pine Bluff (1-7, 0-5) | 17 |
| Texas Southern (2-5, 2-3) | 59 |
| Final | |
| Bluefield State (4-3) | 7 |
| Barton (5-4) | 62 |
| Final | |
| Benedict (4-5, 1-4) | 24 |
| Clark Atlanta (2-7, 0-5) | 21 |
| Final | |
| Howard (2-6, 1-2) | 23 |
| Delaware State (4-4, 1-1) | 30 |
| Final | |
| Livingstone (1-8, 1-5) | 0 |
| 8Fayetteville State (7-1, 6-0) | 34 |
| Final | |
| Savannah State (7-2, 5-1) | 24 |
| Fort Valley State (5-4, 3-2) | 6 |
| Final | |
| 6Albany State (8-1, 5-0) | 14 |
| Morehouse (3-6, 3-2) | 10 |
| Final | |
| SC State (4-4, 3-0) | 27 |
| NC Central (3-5, 1-1) | 24 |
| Final | |
| Morgan State (0-8, 0-4) | 20 |
| 7Norfolk State (6-2, 2-0) | 31 |
| Final | |
| Chowan (6-3, 3-3) | 38 |
| Virginia State (3-5, 3-3) | 30 |
| Final | |
| Alabama State (3-4, 2-3) | 28 |
| Alabama A&M (4-3, 2-3) | 42 |
| Magic City Classic, Birmingham, AL | |
| Final | |
| 1Jackson State (7-1, 5-0) | 28 |
| Miss Valley State (2-6, 1-4) | 19 |
| Final | |
| Grambling State (3-5, 2-3) | 3 |
| 4Florida A&M (6-2, 4-1) | 26 |
| Final | |
| Murray State (3-5, 0-3) | 21 |
| 9Tennessee State (5-3, 3-1) | 27 |
| Final | |
| 3Alcorn (5-3, 4-1) | 35 |
| Southern (4-4, 3-2) | 38 |
| Final | |
| Miles (5-4) | 16 |
| Edward Waters (3-6) | 9 |
| Final | |
| Florida Memorial (1-8, 0-4) | 7 |
| Ave Maria (4-5, 3-1) | 38 |