Saturday, October 23, 2021
| Final | |
| Langston (7-0, 6-0) | 44 |
| Ottawa (6-1, 6-1) | 41 |
| Final | |
| Texas College (0-8, 0-6) | 16 |
| Arizona Christian (5-2, 4-2) | 50 |
| Final | |
| Bethune-Cookman (0-8, 0-5) | 12 |
| 1Jackson State (6-1, 4-0) | 42 |
| Final | |
| Lane (5-3, 2-2) | 21 |
| Tuskegee (3-5, 2-2) | 17 |
| Final | |
| West Virginia State (4-4, 4-3) | 34 |
| Concord (2-5, 2-5) | 32 |
| Final | |
| 10Norfolk State (5-2, 1-0) | 45 |
| Howard (2-5, 1-1) | 31 |
| Final | |
| Miles (4-4, 3-2) | 28 |
| Kentucky State (4-4, 2-2) | 21 |
| Final | |
| NC Central (3-4, 1-0) | 28 |
| Morgan State (0-7, 0-3) | 17 |
| Final | |
| Fayetteville State (6-1, 5-0) | 40 |
| Saint Augustine's (0-6, 0-5) | 12 |
| Final | |
| Johnson C. Smith (0-7, 0-5) | 14 |
| Shaw (5-3, 4-1) | 20 |
| Final | |
| 6Bowie State (7-1, 5-0) | 27 |
| Virginia Union (4-4, 3-2) | 7 |
| Final | |
| Livingstone (1-7, 1-4) | 0 |
| Winston-Salem State (3-4, 3-2) | 21 |
| Final | |
| Chowan (5-3, 2-3) | 28 |
| Elizabeth City State (3-5, 3-2) | 32 |
| Final | |
| Union (1-5, 0-3) | 17 |
| Florida Memorial (1-7, 1-3) | 41 |
| Final | |
| Arkansas-Pine Bluff (1-6) | 3 |
| Arkansas (5-3) | 45 |
| Final | |
| Tennessee State (4-3, 2-1) | 28 |
| Eastern Illinois (1-7, 1-2) | 0 |
| Final | |
| Lincoln (MO) (0-7, 0-7) | 0 |
| Nebraska Kearney (7-1, 7-1) | 56 |
| Final | |
| 8Savannah State (6-2, 4-1) | 0 |
| T-7Albany State (7-1, 4-0) | 30 |
| Final | |
| Morehouse (3-5, 3-1) | 20 |
| Benedict (3-5, 0-4) | 5 |
| Final | |
| SC State (3-4, 2-0) | 13 |
| Delaware State (3-4, 0-1) | 7 |
| Final | |
| Central State (1-7) | 19 |
| Edward Waters (3-5) | 56 |
| Final | |
| Clark Atlanta (2-6, 0-4) | 7 |
| Fort Valley State (5-3, 3-1) | 40 |
| Final | |
| 5NC A&T (3-4, 2-2) | 9 |
| Hampton (3-4, 1-2) | 30 |
| Final | |
| Lincoln (PA) (1-7, 1-4) | 3 |
| Virginia State (3-4, 3-2) | 23 |
| Final | |
| 4Florida A&M (5-2, 3-1) | 31 |
| Miss Valley State (2-5, 1-3) | 28 |
| Final | |
| Allen (3-4) | 40 |
| Erskine (3-5) | 47 |
| Final | |
| 2Prairie View A&M (6-1, 5-0) | 48 |
| T-7Southern (3-4, 2-2) | 21 |
| Final | |
| 3Alcorn (5-2, 4-0) | 44 |
| Texas Southern (1-5, 1-3) | 27 |