Friday, October 8, 2021
| Final | |
| Morgan State (0-5, 0-1) | 0 |
| Howard (2-4, 1-0) | 27 |
| ESPNU | |
Saturday, October 9, 2021
| Final | |
| Miss Valley State (2-3, 1-1) | 20 |
| Bethune-Cookman (0-6, 0-3) | 14 |
| Final | |
| West Virginia State (3-3, 3-2) | 38 |
| West Virginia Wesleyan (0-6, 0-5) | 3 |
| Final | |
| Fort Lauderdale (0-4) | 9 |
| Bluefield State (3-1) | 23 |
| Final | |
| 8Bowie State (5-1, 3-0) | 14 |
| 9Chowan (5-1, 2-1) | 3 |
| Final | |
| Winston-Salem State (1-4, 1-2) | 26 |
| Johnson C. Smith (0-5, 0-3) | 12 |
| Final | |
| Lane (4-2, 0-1) | 14 |
| Kentucky State (3-3, 2-1) | 49 |
| Final | |
| North Alabama (0-6, 0-2) | 34 |
| 2NC A&T (3-2, 2-0) | 38 |
| Final | |
| Fayetteville State (4-1, 3-0) | 15 |
| Shaw (3-3, 2-1) | 12 |
| Final | |
| Lincoln (PA) (0-6, 0-3) | 0 |
| Virginia Union (3-3, 2-1) | 32 |
| Final | |
| Warner (3-3, 1-1) | 31 |
| Florida Memorial (0-7, 0-3) | 12 |
| Final | |
| Saint Augustine's (0-4, 0-3) | 7 |
| Livingstone (1-5, 1-2) | 21 |
| Final | |
| 1Jackson State (4-1, 2-0) | 61 |
| 5Alabama A&M (3-2, 1-2) | 15 |
| Final | |
| Arkansas-Pine Bluff (1-4, 0-3) | 15 |
| Alabama State (3-2 ,2-1) | 35 |
| Final | |
| Grambling State (2-4, 1-2) | 20 |
| 4Alcorn State (3-2, 2-0) | 24 |
| Final | |
| Missouri Southern (2-4, 2-4) | 52 |
| Lincoln (MO) (0-5, 0-5) | 32 |
| Final | |
| Edward Waters (2-4) | 0 |
| Albany State (5-1) | 30 |
| Final | |
| Allen (3-3) | 12 |
| Clark Atlanta (2-4) | 21 |
| Final | |
| VA-Lynchburg (0-5) | 6 |
| Delaware State (3-3) | 56 |
| Final | |
| Central State (1-5, 0-2) | 14 |
| Fort Valley State (4-2, 2-0) | 35 |
| Final | |
| Kennesaw State (4-1, 1-0) | 34 |
| Hampton (2-3, 0-1) | 15 |
| Final | |
| Tennessee Tech (2-4) | 27 |
| NC Central (2-4) | 16 |
| Final | |
| Benedict (3-3, 1-3) | 24 |
| Miles (2-4, 1-2) | 21 |
| Final | |
| 7Southern (2-3, 1-1) | 31 |
| Texas Southern (2-3, 1-1) | 35 |
| Final | |
| 10SC State (1-4) | 7 |
| 6Florida A&M (3-2) | 30 |
| Final | |
| Erskine (1-5) | 6 |
| Savannah State (5-1) | 39 |
| Final | |
| Elizabeth City State (2-4, 2-1) | 7 |
| Virginia State (2-3, 2-1) | 35 |
| Final | |
| Morehouse (1-5, 1-1) | 31 |
| Tuskegee (2-4, 1-1) | 15 |
| Morhouse-Tuskegee Football Classic, Birmingham, AL | |
| Final | |
| Ottawa (6-0, 6-0) | 48 |
| Texas College (0-6, 0-4) | 6 |