Thursday, September 30, 2021
| Final | |
| 7Arkansas-Pine Bluff (1-3, 0-2) | 17 |
| 4Prairie View A&M (4-1, 3-0) | 27 |
| ESPNU | |
Saturday, October 2, 2021
| Final | |
| Clark Atlanta (1-4, 0-3) | 0 |
| Tuskegee (2-3, 1-0) | 21 |
| Final | |
| Allen (3-2) | 46 |
| Central State (1-4) | 34 |
| Final | |
| Sacred Heart (2-3) | 17 |
| Howard (1-4) | 22 |
| Final | |
| Savannah State (3-1, 3-0) | 21 |
| Kentucky State (2-3, 1-1) | 17 |
| Final | |
| Robert Morris (1-2, 0-1) | 14 |
| 3NC A&T (2-2, 1-0) | 41 |
| Final | |
| Shaw (3-2, 2-0) | 27 |
| Virginia Union (2-3, 1-1) | 7 |
| Final | |
| Livingstone (0-5, 0-2) | 13 |
| Elizabeth City State (2-3, 2-0) | 19 |
| Final | |
| Keiser (3-1, 1-0) | 31 |
| Florida Memorial (0-6, 0-2) | 26 |
| Final | |
| Bethune-Cookman (0-5) | 35 |
| SC State (1-3) | 42 |
| Final | |
| Saint Francis (PA) (2-3) | 27 |
| Morgan State (0-4) | 14 |
| Final | |
| Lincoln (MO) (0-4, 0-4) | 28 |
| Central Oklahoma (2-3, 2-3) | 69 |
| Final | |
| 1Alabama A&M (3-1, 1-1) | 28 |
| Grambling State (2-3, 1-1) | 37 |
| Final | |
| Texas College (0-5) | 0 |
| Lane (4-1) | 71 |
| Final | |
| Langston (5-0, 4-0) | 30 |
| Lyon (0-5, 0-4) | 0 |
| Final | |
| North American (2-3) | 0 |
| Texas Southern (1-3) | 69 |
| Final | |
| Fort Valley State (3-2, 1-0) | 24 |
| Benedict (2-3, 0-3) | 14 |
| Final | |
| Johnson C. Smith (0-4, 0-2) | 7 |
| 10Bowie State (4-1, 2-0) | 44 |
| Final OT | |
| Norfolk State (3-2) | 47 |
| Hampton (2-2) | 44 |
| Battle of the Bay, Hampton VA | |
| Final | |
| Edward Waters (2-3) | 37 |
| Morehouse (0-5) | 13 |
| Final | |
| 9NC Central (2-3) | 16 |
| Miss Valley State (1-3) | 17 |
| Final 2OT | |
| Delaware State (2-3) | 33 |
| Wagner (0-5) | 27 |
| Final | |
| Albany State (4-1, 2-0) | 31 |
| Miles (2-3, 1-1) | 3 |
| Final | |
| Winston-Salem State (0-4, 0-2) | 7 |
| Chowan (5-0, 2-0) | 73 |
| Final | |
| Alabama State (2-2, 1-1) | 0 |
| 6Florida A&M (2-2, 1-1) | 28 |
| Final | |
| Saint Augustine (0-3, 0-2) | 9 |
| Virginia State (1-3, 1-1) | 33 |
| Final | |
| Tennessee State (2-3, 1-1) | 24 |
| Austin Peay (2-3, 0-1) | 22 |
| Final | |
| Lincoln (PA) (0-5, 0-2) | 9 |
| Fayetteville State (3-1, 2-0) | 46 |
| Final | |
| Alderson Broaddus (0-5, 0-4) | 13 |
| West Virginia State (2-3, 2-2) | 45 |
| Final | |
| VA-Lynchburg (0-4) | 13 |
| Erskine (1-4) | 59 |