Saturday, November 13, 2021
| Final | |
| Kentucky State (7-4) | 41 |
| Erskine (3-8) | 17 |
| Final | |
| 5Albany State (9-1, 6-0) | 31 |
| Miles (6-5, 4-3) | 0 |
| SIAC Championship, Atlanta, GA | |
| Final | |
| Charleston (8-2, 8-2) | 38 |
| West Virginia State (6-5, 6-4) | 13 |
| Final | |
| Alabama State (3-6, 2-5) | 31 |
| Miss Valley State (3-7, 2-5) | 44 |
| Final | |
| Morgan State (1-9) | 14 |
| Albany (2-8) | 41 |
| Final | |
| Edward Waters (4-7) | 51 |
| Allen (4-5) | 34 |
| Final | |
| 6Fayetteville State (8-2) | 7 |
| 4Bowie State (10-1) | 17 |
| CIAA Championship, Salem, VA | |
| Final | |
| Hampton (5-5, 3-3) | 28 |
| Campbell (3-7, 2-4) | 21 |
| Final | |
| 7Norfolk State (6-4, 2-2) | 26 |
| Delaware State (5-5, 2-2) | 28 |
| Final | |
| NC Central (5-5, 3-1) | 45 |
| Howard (2-8, 1-4) | 27 |
| Final | |
| NC A&T (5-5) | 27 |
| 8SC State (5-5) | 17 |
| Final | |
| Bethune-Cookman (2-8, 2-5) | 31 |
| Grambling State (3-7, 2-5) | 14 |
| Final | |
| Missouri Western (6-5, 6-5) | 41 |
| Lincoln (MO) (0-10, 0-10) | 12 |
| Final | |
| 2Prairie View A&M (7-2, 6-1) | 29 |
| Alcorn State (6-4, 5-2) | 31 |
| Final | |
| 3Florida A&M (8-2, 6-1) | 37 |
| Arkansas-Pine Bluff (2-8, 1-6) | 7 |
| Final | |
| Texas College (0-11, 0-9) | 12 |
| Louisiana College (3-8, 3-6) | 77 |
| Final | |
| Austin Peay (5-5, 3-2) | 36 |
| 9Tennessee State (5-5, 3-3) | 7 |
| Final | |
| Alabama A&M (6-3, 4-3) | 52 |
| Texas Southern (2-7, 2-5) | 49 |
| Final | |
| SAGU (8-3, 6-3) | 41 |
| Langston (7-3, 6-3) | 24 |
| Final | |
| 1Jackson State (9-1, 7-0) | 21 |
| Southern (4-6, 3-4) | 17 |
| Final | |
| Florida Memorial (2-9, 1-5) | 7 |
| Southeastern (8-3, 5-1) | 28 |