Saturday, April 10, 2021
| Final | |
| West Virginia State (2-2, 2-2) | 10 |
| Charleston (3-0, 3-0) | 39 |
| TV/Radio: N/A | |
| Final | |
| Ottawa (4-1, 4-1) | 28 |
| Langston (2-3, 2-3) | 24 |
| TV/Radio: N/A | |
| Cancelled | |
| Lincoln (MO) (0-2) | -- |
| East Central (2-0) | -- |
| TV/Radio: N/A | |
| Final | |
| Mississippi Valley State (1-3, 1-3) | 17 |
| 6 Alabama State (3-2, 3-1) | 42 |
| TV/Radio: N/A | |
| Final | |
| 1 Alabama A&M (3-0, 2-0) | 52 |
| 7 Jackson State (3-3, 2-2) | 43 |
| TV/Radio: ESPN | |
| Final | |
| Fort Valley State (2-0) | 45 |
| Erskine (1-5) | 21 |
| TV/Radio: ESPN | |
| 6:00p.m. | |
| Delaware (4-0) | 34 |
| 8 Delaware State (2-2) | 14 |
| TV/Radio: N/A | |
| Postponed | |
| 3 Southern (4-1, 3-1) | -- |
| 4 Prairie View A&M (2-0, 2-0) | -- |
| TV/Radio: N/A | |
Sunday, April 11, 2021
| Final | |
| Southeast Missouri (4-4, 4-3) | 46 |
| 9 Tennessee State (2-5, 2-5) | 23 |
| TV/Radio: N/A | |