Saturday, October 16, 2021
| Final | |
| 5Florida A&M (4-2, 2-1) | 35 |
| 8Alabama A&M (3-3, 1-3) | 31 |
| Final | |
| Lincoln (MO) (0-6, 0-6) | 7 |
| Pittsburg State (5-2, 5-2) | 59 |
| Final | |
| Virginia State (2-4, 2-2) | 44 |
| 6Bowie State (6-1, 4-0) | 51 |
| Final | |
| Tuskegee (3-4, 2-1) | 29 |
| Central State (1-6, 0-4) | 0 |
| Final | |
| Virginia Union (4-3, 3-1) | 38 |
| 9Chowan (5-2, 2-2) | 31 |
| Final | |
| Kentucky State (4-3) | 76 |
| Edward Waters (2-5) | 36 |
| Final | |
| Elizabeth City State (2-5, 2-2) | 14 |
| Lincoln (PA) (1-6, 1-3) | 17 |
| Final | |
| Shaw (4-3, 3-1) | 20 |
| Livingstone (1-6, 1-3) | 9 |
| Final | |
| Morgan State (0-6, 0-2) | 14 |
| SC State (2-4, 1-0) | 37 |
| ESPNU | |
| Final | |
| Saint Augustine's (0-5, 0-4) | 0 |
| Winston-Salem State (2-4, 2-2) | 41 |
| Final | |
| 9Southern (3-3, 2-1) | 34 |
| Arkansas-Pine Bluff (1-5, 0-4) | 7 |
| Final | |
| Texas Southern (2-4, 1-2) | 20 |
| Grambling State (3-4, 2-2) | 34 |
| Final | |
| Alabama State (3-3, 2-2) | 7 |
| 1Jackson State (5-1, 3-0) | 28 |
| Final | |
| Miles (3-4, 2-2) | 34 |
| Lane (4-3, 1-2) | 31 |
| Final | |
| Texas Wesleyan (4-2, 4-2) | 31 |
| Langston (6-0, 5-0) | 42 |
| Final OT | |
| Tennessee Tech (2-5, 1-2) | 13 |
| Tennessee State (3-3, 1-1) | 20 |
| Final | |
| 7Albany State (6-1, 3-0) | 28 |
| Benedict (3-4, 0-3) | 6 |
| Final | |
| Johnson C. Smith (0-6, 0-4) | 12 |
| Fayetteville State (5-1, 4-0) | 55 |
| Final | |
| Fort Valley State (4-3, 2-1) | 3 |
| Morehouse (2-5, 2-1) | 51 |
| Final | |
| VA-Lynchburg (0-6) | 14 |
| Norfolk State (4-2) | 42 |
| Final | |
| 4Alcorn State (4-2, 3-0) | 24 |
| Miss Valley State (2-4, 1-2) | 12 |
| Final | |
| 3Prairie View A&M (5-1, 4-0) | 35 |
| Bethune-Cookman (0-7, 0-4) | 29 |
| Final | |
| Clark Atlanta (2-5, 0-3) | 14 |
| 10Savannah State (6-1, 4-0) | 49 |
| Final | |
| Bluefield State (4-2) | 19 |
| Erskine (2-5) | 24 |
| Final | |
| 2NC A&T (3-3, 2-1) | 0 |
| Kennesaw State (5-1, 2-0) | 14 |
| Final | |
| Lyon (1-6, 1-5) | 33 |
| Texas College (0-7, 0-5) | 32 |
| Final | |
| Hampton(2-4, 0-2) | 5 |
| Charleston Southern (2-3, 1-2) | 35 |
| 6:00p.m. | |
| UNC Pembroke (4-3, 4-2) | 14 |
| West Virginia State (3-4, 3-3) | 13 |