Thursday, November 25, 2021
| Final | |
| Tuskegee (3-8) | 9 |
| Alabama State (5-6) | 43 |
| Turkey Day Classic, Montgomery, AL | |
Saturday, November 27, 2021
| Final | |
| Newberry (10-3) | 10 |
| 3 Bowie State (12-1) | 13 |
| Second Round, Division II Playoffs, Bowie, MD | |
| Final | |
| Miss Valley State (4-7, 3-5) | 24 |
| 4 Prairie View A&M (7-4, 6-2) | 19 |
| Final | |
| Southern (4-7, 3-5) | 26 |
| Grambling State (4-7, 3-5) | 29 |
| Bayou Classic, New Orleans, LA | |
| Final | |
| 2 Florida A&M (9-3) | 14 |
| Southeastern Louisiana (9-3) | 38 |
| First Round, FCS Playoffs, Hammond, LA | |