Saturday, November 20, 2021
| Final | |
| Arkansas-Pine Bluff (2-9, 1-7) | 24 |
| 10Alabama A&M (7-3, 5-3) | 52 |
| Final | |
| T-6Alcorn State (6-5, 5-3) | 10 |
| 1Jackson State (10-1, 8-0) | 24 |
| Final | |
| West Georgia (9-2) | 23 |
| 5Albany State (9-2) | 7 |
| Final | |
| Lenoir-Rhyne (8-3) | 10 |
| 3Bowie State (11-1) | 31 |
| Final | |
| North Alabama (3-8, 2-4) | 35 |
| Hampton (5-6, 3-4) | 27 |
| 2:00p.m. | |
| VA-Lynchburg (0-8) | -- |
| Howard (2-8) | -- |
| Final | |
| Gardner-Webb (4-7, 2-5) | 35 |
| NC A&T (5-6, 3-4) | 27 |
| Final | |
| Tennessee State (5-6) | 10 |
| Mississippi State (7-4) | 55 |
| Final | |
| 4Prairie View A&M (7-3) | 3 |
| Texas A&M (8-3) | 52 |
| Final | |
| Georgetown (2-8) | 21 |
| Morgan State (2-9) | 28 |
| Final | |
| Texas Southern (2-8, 2-6) | 21 |
| Alabama State (4-6, 3-5) | 24 |
| Final OT | |
| Delaware State (5-6, 2-3) | 28 |
| NC Central (6-5, 4-1) | 34 |
| Final | |
| SC State (6-5, 5-0) | 31 |
| 9 Norfolk State (6-5, 2-3) | 21 |
| Final | |
| 2Florida A&M (9-2, 7-1) | 46 |
| Bethune-Cookman (2-9, 2-6) | 21 |
| Florida Classic, Orlando, FL | |