Saturday, April 17, 2021
| Final | |
| 10 Grambling State (0-4, 0-4) | 7 |
| 3 Southern (5-1, 4-1) | 49 |
| TV/Radio: NBC Sports Network | |
| Postponed | |
| Mississippi Valley State (1-3, 1-3) | -- |
| Texas Southern (0-2, 0-2) | -- |
| Final-OT | |
| 6 South Carolina State (3-1) | 31 |
| 8 Delaware State (2-3) | 28 |
| Final | |
| 4 Prairie View A&M (2-1, 2-1) | 31 |
| 2 Arkansas-Pine Bluff (4-0, 4-0) | 36 |
| Final | |
| 5 Alabama State (3-3, 3-2) | 14 |
| 1 Alabama A&M (4-0, 3-0) | 38 |
| TV/Radio: ESPNU | |
| Canceled | |
| 7 Jackson State (3-3, 2-2) | -- |
| Alcorn State (0-5, 0-5) | -- |